OhioHealth is expected to help anchor the new Gateway at Hilliard development with a 35,000-square-foot medical center.
Continental Real Estate is developing the 56-acre parcel at the northwest corner of Cemetery Road and Britton Parkway.
It will include the OhioHealth Hilliard Health Center, a Giant Eagle store, about 450 apartments, restaurants, gas stations and other offices and retail businesses.
Hilliard officials expect the OhioHealth center to open in January.
"We are excited about OhioHealth opening," said Hilliard Economic Development Director David Meeks.
OhioHealth spokeswoman Christina Fitzer said the project would create the equivalent of 20 new full-time jobs and transfer the equivalent of 30 full-time jobs to Hilliard.
Meeks said the project will benefit residents by providing additional medical services and will allow the city to collect additional payroll taxes.
The city is expected to receive about $520,000 annually of income-tax withholding revenue from the entire Gateway development, Meeks said.
OhioHealth will lease most of the 45,000-square-foot building from Continental, which plans to build a second 45,000-square-foot building on the site.
Each building will cost $8.1 million, said Frank Kass of Continental Real Estate. The estimated payroll for one building is $9 million, he said.
The OhioHealth Hilliard Health Center will centralize a variety of services relocating from five other locations, including those in Mill Run.
Similar centralized OhioHealth campuses have been developed in Westerville, Dublin, Upper Arlington, Gahanna and Grove City.
Expected practices at the health center include Orthopaedic Specialists of Central Ohio, DeWalt Family Medicine at Mill Run, The Doctor's Office at Hilliard Square, MAX Sports Medicine and Hilliard Sports Medicine and Rehabilitation.
In addition to the practices relocating to the campus, OhioHealth will provide new services including an Urgent Care; laboratory services; expanded rehabilitation services, including physical therapy and hand therapy; and advanced diagnostics, including MRI and X-ray imaging.
Sean Huffman, president of OhioHealth Neighborhood Care, described the campus as "very comprehensive."
"No matter where a patient joins the OhioHealth network, whether at Urgent Care or for physical therapy after surgery at a hospital, this center will provide all those services at one place," Huffman said. "This campus represents a tremendous group of physicians and ancillary services in one building.
"We're excited about it, but we are equally excited for our patients."
The Hilliard campus would be mid-sized compared to other OhioHealth complexes. Huffman compared it to the center in Gahanna.
The campus' proximity to a retail pharmacy such as Giant Eagle provides will benefit residents, Huffman said.
The new location also will be the base of operations for athletic trainers for the school district's three high schools and three middle schools.