The American Association for Cancer Research honored Dr. Carlo Croce, professor and chairman of the department of molecular virology, immunology and medical genetics and director of Human Cancer Genetics at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, with the seventh annual Princess Takamatsu Memorial Lectureship at the recent AACR Annual Meeting 2013 held in Washington, D.C.
Croce, an Upper Arlington resident who presented the lecture "Causes and Consequences of microRNA Dysregulation in Cancer," was recognized for his research into the genetic mechanisms of cancer. He discovered numerous oncogenes and established the role of microRNAs in the development and progression of cancer.
The AACR Princess Takamatsu Memorial Lectureship is presented to a scientist whose novel and significant work had or may have a far-reaching impact on the detection, diagnosis, treatment or prevention of cancer, and who embodies the dedication of the princess to multinational collaborations. Her Imperial Highness Princess Kikuko Takamatsu was instrumental in promoting cancer research and encouraging cancer scientists. She became a champion for these causes following her mother's death from bowel cancer in 1933 at age 43.
Croce started his quest to find cancer-causing genes by analyzing cancer-specific genomic abnormalities called chromosomal translocations. He began by studying the translocation that characterizes Burkitt's lymphoma and showing that it led to the activation of the oncogene MYC. This finding was instrumental in determining that the chromosomal translocations observed in many human leukemias and lymphomas deregulate oncogenes, initiating the process of leukemia or lymphoma development.
His research led to the development of a microRNA gene expression chip to assess global expression of microRNAs in tissues and tumors.
In addition to being honored at the AACR Annual Meeting 2013 with the AACR Princess Takamatsu Memorial Lectureship, Croce was inaugurated into the first class of the Fellows of the AACR Academy. Croce has received numerous recognitions throughout his career, including two Outstanding Investigator Awards from the National Cancer Institute, the Raymond Bourgine Award and Gold Medal of Paris and an honorary doctorate in medicine from Uppsala University in Sweden.